Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.15 (overall 0.10) | 0.15 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in pancreatic islet cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 4 Parkinson's papers of 71 | 0.79 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2754
Sealed predictions
- SYT4 in dopamine neurons, braak+0.37 (p 0.329) → +0.72 (p 0.029)receipt 2761
Swarm cases
receipt 2761: SYT4 in dopamine neurons, braak
- power
- full sample +0.57 (p 0.013, n 18), 95% CI +0.14 to +0.82. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.55 (p 0.018, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.61 (p 0.0077, n 18). not the mix.
- skeptic
- leave-one-out range +0.52 to +0.64, sign flips 0; without severely affected donors +0.57 (p 0.013, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SYT4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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