parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.35 (overall 0.21)	0.35
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in ependymal cells	0.75
chemistry Open Targets	hard to drug	0.27
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 16	0.91
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 1964

receipt 1970: SYT17 in dopamine neurons, braak

power: full sample -0.11 (p 0.671, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.08 (p 0.767, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.218, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.03, sign flips 1; without severely affected donors -0.11 (p 0.671, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SYT17 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1969: SYT17 in astrocytes, braak

power: full sample -0.08 (p 0.754, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.05 (p 0.834, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.08 (p 0.754, n 18). could be the mix.
skeptic: leave-one-out range -0.21 to +0.05, sign flips 3; without severely affected donors -0.08 (p 0.754, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SYT17 in astrocytes.

case closed: nothing better to follow up.

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