Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.04 (overall 0.06) | 0.04 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in retinal amacrine cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 12 Parkinson's papers of 159 | 0.66 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4452
Sealed predictions
- STX1B in dopamine neurons, braak-0.40 (p 0.285) → +0.00 (p 1.000)receipt 4459
Swarm cases
receipt 4459: STX1B in dopamine neurons, braak
- power
- full sample -0.29 (p 0.235, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.30 (p 0.221, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.34 (p 0.161, n 18). could be the mix.
- skeptic
- leave-one-out range -0.43 to -0.20, sign flips 0; without severely affected donors -0.29 (p 0.235, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for STX1B in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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