Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in pancreatic islet cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 6 Parkinson's papers of 391 | 0.74 |
| pathways Reactome | 14 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 6994
Sealed predictions
- STX1A in dopamine neurons, braak-0.53 (p 0.140) → -0.39 (p 0.297)receipt 7001
In the sealed studies
- The synaptic vesicle cycle in resilient donors: did not hold
Swarm cases
receipt 7001: STX1A in dopamine neurons, braak
- power
- full sample -0.46 (p 0.057, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.40 (p 0.101, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.033, n 18). not the mix.
- skeptic
- leave-one-out range -0.57 to -0.38, sign flips 0; without severely affected donors -0.46 (p 0.057, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for STX1A in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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