parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.07 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocyte progenitor cells; strongest in foveolar cells	0.75
chemistry Open Targets	a small-molecule pocket: lutetium oxodotreotide lu-177, octreotide acetate, somatostatin +5	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 571	0.82
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 3634

receipt 3643: SSTR1 in dopamine neurons, braak

power: full sample +0.04 (p 0.861, n 18), 95% CI -0.43 to +0.50. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.00 (p 0.990, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.02 (p 0.949, n 18). could be the mix.
skeptic: leave-one-out range -0.07 to +0.17, sign flips 5; without severely affected donors +0.04 (p 0.861, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SSTR1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3642: SSTR1 in oligodendrocytes, braak

power: full sample -0.34 (p 0.161, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.34 (p 0.170, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.30 (p 0.232, n 18). could be the mix.
skeptic: leave-one-out range -0.46 to -0.24, sign flips 0; without severely affected donors -0.34 (p 0.161, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SSTR1 in oligodendrocytes.

case closed: nothing better to follow up.

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