Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.38 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 10 Parkinson's papers of 1,067 | 0.69 |
| pathways Reactome | 8 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 0700
Sealed predictions
- SREBF1 in dopamine neurons, braak-0.62 (p 0.073) → -0.47 (p 0.197)receipt 0705
Swarm cases
receipt 0705: SREBF1 in dopamine neurons, braak
- power
- full sample -0.50 (p 0.036, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.45 (p 0.059, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.093, n 18). could be the mix.
- skeptic
- leave-one-out range -0.66 to -0.42, sign flips 0; without severely affected donors -0.50 (p 0.036, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SREBF1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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