Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

SPPL2C

signal peptide peptidase like 2C

translation score 0.34, read 2026-10-19; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
genetic association 0.14 (overall 0.09)0.14
cell type
Human Protein Atlas
not detected in single-cell data0.00
chemistry
Open Targets
reachable by antibody0.36
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
4 Parkinson's papers of 250.79
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 2865

Sealed predictions

  1. SPPL2C in dopamine neurons, braakn/a → n/areceipt 2871

Swarm cases

receipt 2871: SPPL2C in dopamine neurons, braak

cell type
SPPL2C is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SPPL2C in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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