Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.06 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 31 Parkinson's papers of 319 | 0.54 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 4379
Sealed predictions
- SPG11 in dopamine neurons, braak+0.37 (p 0.321) → -0.75 (p 0.019)receipt 4386
Swarm cases
receipt 4386: SPG11 in dopamine neurons, braak
- power
- full sample -0.28 (p 0.269, n 18), 95% CI -0.66 to +0.22. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.19 (p 0.460, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.10 (p 0.683, n 18). could be the mix.
- skeptic
- leave-one-out range -0.44 to -0.19, sign flips 0; without severely affected donors -0.28 (p 0.269, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SPG11 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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