Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

SP9

Sp9 transcription factor

translation score 0.43, read 2026-10-21; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.06 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced in brain inhibitory neurons (6 nCPM)1.00
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
1 Parkinson's trial, 0 stopped1.00
literature
PubMed
1 Parkinson's papers of 2110.91
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 4776

Sealed predictions

  1. SP9 in dopamine neurons, braakn/a → n/areceipt 4783

Swarm cases

receipt 4783: SP9 in dopamine neurons, braak

cell type
SP9 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SP9 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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