Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 10 Parkinson's papers of 5,880 | 0.69 |
| pathways Reactome | 1 pathway; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 7375
Sealed predictions
- SP3 in dopamine neurons, braak+0.31 (p 0.414) → -0.15 (p 0.697)receipt 7382
Swarm cases
receipt 7382: SP3 in dopamine neurons, braak
- power
- full sample +0.07 (p 0.794, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.03 (p 0.901, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.09 (p 0.728, n 18). could be the mix.
- skeptic
- leave-one-out range -0.01 to +0.21, sign flips 4; without severely affected donors +0.07 (p 0.794, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SP3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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