Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.46 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 2 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 61 Parkinson's papers of 13,661 | 0.46 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 0314
Sealed predictions
- SON in dopamine neurons, braak-0.01 (p 0.982) → +0.26 (p 0.501)receipt 0321
Swarm cases
receipt 0321: SON in dopamine neurons, braak
- power
- full sample +0.17 (p 0.509, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.677, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.32 (p 0.201, n 18). could be the mix.
- skeptic
- leave-one-out range +0.06 to +0.32, sign flips 0; without severely affected donors +0.17 (p 0.509, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SON in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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