Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.29 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocyte progenitor cells (2991 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1350
Sealed predictions
- SNTG1 in dopamine neurons, braak+0.27 (p 0.484) → +0.39 (p 0.299)receipt 1358
- SNTG1 in oligodendrocytes, braak-0.29 (p 0.456) → +0.62 (p 0.073)receipt 1357
Swarm cases
receipt 1358: SNTG1 in dopamine neurons, braak
- power
- full sample +0.40 (p 0.101, n 18), 95% CI -0.08 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.43 (p 0.079, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.43 (p 0.079, n 18). could be the mix.
- skeptic
- leave-one-out range +0.32 to +0.60, sign flips 0; without severely affected donors +0.40 (p 0.101, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SNTG1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 1357: SNTG1 in oligodendrocytes, braak
- power
- full sample +0.02 (p 0.949, n 18), 95% CI -0.45 to +0.48. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.05 (p 0.840, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.03 (p 0.894, n 18). could be the mix.
- skeptic
- leave-one-out range -0.10 to +0.16, sign flips 6; without severely affected donors +0.02 (p 0.949, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SNTG1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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