Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.21 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 243 | 0.82 |
| pathways Reactome | 2 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 2003
Sealed predictions
- SNAP29 in dopamine neurons, braak-0.23 (p 0.545) → +0.01 (p 0.982)receipt 2010
Swarm cases
receipt 2010: SNAP29 in dopamine neurons, braak
- power
- full sample -0.14 (p 0.573, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.09 (p 0.709, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.13 (p 0.609, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.04, sign flips 0; without severely affected donors -0.14 (p 0.573, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SNAP29 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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