Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.14 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in brain excitatory neurons (1192 nCPM) | 1.00 |
| chemistry Open Targets | a small-molecule pocket: botulinum toxin type a, trenibotulinumtoxine, incobotulinumtoxina +5 | 0.60 |
| trials ClinicalTrials.gov | 21 Parkinson's trials, 3 stopped | 0.89 |
| literature PubMed | 107 Parkinson's papers of 3,018 | 0.38 |
| pathways Reactome | 13 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 2220
Sealed predictions
- SNAP25 in dopamine neurons, braak+0.08 (p 0.842) → +0.46 (p 0.212)receipt 2226
In the sealed studies
- The synaptic vesicle cycle in resilient donors: did not hold
Swarm cases
receipt 2226: SNAP25 in dopamine neurons, braak
- power
- full sample +0.31 (p 0.218, n 18), 95% CI -0.19 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.27 (p 0.273, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.13 (p 0.609, n 18). could be the mix.
- skeptic
- leave-one-out range +0.22 to +0.42, sign flips 0; without severely affected donors +0.31 (p 0.218, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SNAP25 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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