Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.28 (overall 0.17) | 0.28 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 346 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2135
Sealed predictions
- SMYD3 in dopamine neurons, braak+0.13 (p 0.732) → +0.12 (p 0.756)receipt 2141
Swarm cases
receipt 2141: SMYD3 in dopamine neurons, braak
- power
- full sample +0.08 (p 0.748, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.03 (p 0.908, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.748, n 18). could be the mix.
- skeptic
- leave-one-out range -0.06 to +0.20, sign flips 4; without severely affected donors +0.08 (p 0.748, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SMYD3 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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