Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 6,341 | 0.74 |
| pathways Reactome | 21 pathways; mostly iron and oxidative stress | 0.80 |
No case: the score is under the bar. Receipt 10629
Sealed predictions
- SMAD4 in dopamine neurons, braak+0.07 (p 0.859) → +0.80 (p 0.009)receipt 10637
Swarm cases
receipt 10637: SMAD4 in dopamine neurons, braak
- power
- full sample +0.37 (p 0.127, n 18), 95% CI -0.11 to +0.72. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.39 (p 0.105, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.093, n 18). could be the mix.
- skeptic
- leave-one-out range +0.30 to +0.54, sign flips 0; without severely affected donors +0.37 (p 0.127, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SMAD4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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