Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.31 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in gonadotrophs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1228
Sealed predictions
- SLC7A14 in dopamine neurons, braak+0.44 (p 0.237) → -0.26 (p 0.493)receipt 1236
- SLC7A14 in oligodendrocytes, braak-0.11 (p 0.784) → -0.03 (p 0.947)receipt 1235
Swarm cases
receipt 1236: SLC7A14 in dopamine neurons, braak
- power
- full sample +0.13 (p 0.603, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.17 (p 0.509, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.08 (p 0.754, n 18). could be the mix.
- skeptic
- leave-one-out range +0.02 to +0.23, sign flips 0; without severely affected donors +0.13 (p 0.603, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC7A14 in dopamine neurons.
case closed: nothing better to follow up.
receipt 1235: SLC7A14 in oligodendrocytes, braak
- power
- full sample -0.08 (p 0.761, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.761, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.16 (p 0.515, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.07, sign flips 2; without severely affected donors -0.08 (p 0.761, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC7A14 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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