Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.09 (overall 0.06) | 0.09 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 4782
Sealed predictions
- SLC35F5 in dopamine neurons, braak+0.77 (p 0.015) → +0.00 (p 1.000)receipt 4789
Swarm cases
receipt 4789: SLC35F5 in dopamine neurons, braak
- power
- full sample +0.42 (p 0.082, n 18), 95% CI -0.06 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.47 (p 0.050, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.64 (p 0.0044, n 18). not the mix.
- skeptic
- leave-one-out range +0.35 to +0.59, sign flips 0; without severely affected donors +0.42 (p 0.082, n 18). robust.
- cell type
- strongest in microglia: -0.62 (p 0.0060, n 18) vs +0.42 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC35F5 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SLC35F5 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.75 p 0.0077 (needs p < 4.1e-4)
Receipts
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