Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

SIX6

SIX homeobox 6

translation score 0.32, read 2026-10-17; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.27 from other evidence0.00
cell type
Human Protein Atlas
cell type enhanced outside the brain (müller glia)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
2 Parkinson's trials, 0 stopped1.00
literature
PubMed
no papers tie it to Parkinson's yet1.00
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 1487

Sealed predictions

  1. SIX6 in dopamine neurons, braakn/a → n/areceipt 1494

Swarm cases

receipt 1494: SIX6 in dopamine neurons, braak

cell type
SIX6 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for SIX6 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

loading the receipts