parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.11 from other evidence	0.00
cell type Human Protein Atlas	group enriched in oligodendrocytes (303 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	79 Parkinson's papers of 1,723	0.42
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 2396

receipt 2403: SIRT2 in dopamine neurons, braak

power: full sample +0.29 (p 0.246, n 18), 95% CI -0.21 to +0.67. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.28 (p 0.258, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.38 (p 0.123, n 18). could be the mix.
skeptic: leave-one-out range +0.22 to +0.43, sign flips 0; without severely affected donors +0.29 (p 0.246, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SIRT2 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2402: SIRT2 in oligodendrocytes, braak

power: full sample -0.16 (p 0.521, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.31 (p 0.207, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.26 (p 0.302, n 18). could be the mix.
skeptic: leave-one-out range -0.30 to -0.06, sign flips 0; without severely affected donors -0.16 (p 0.521, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SIRT2 in oligodendrocytes.

case closed: nothing better to follow up.

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