parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.30 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in neutrophils	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 1297

receipt 1305: SIK3 in dopamine neurons, braak

power: full sample +0.22 (p 0.389, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.20 (p 0.429, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.218, n 18). could be the mix.
skeptic: leave-one-out range +0.11 to +0.35, sign flips 0; without severely affected donors +0.22 (p 0.389, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SIK3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 1304: SIK3 in oligodendrocytes, braak

power: full sample -0.04 (p 0.888, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.00 (p 0.990, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.01 (p 0.976, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.08, sign flips 4; without severely affected donors -0.04 (p 0.888, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SIK3 in oligodendrocytes.

case closed: nothing better to follow up.

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