Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced outside the brain (urothelial cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 123 Parkinson's papers of 8,556 | 0.37 |
| pathways Reactome | 11 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7141
Sealed predictions
- SHH in dopamine neurons, braak-0.78 (p 0.014) → -0.04 (p 0.910)receipt 7149
Swarm cases
receipt 7149: SHH in dopamine neurons, braak
- power
- full sample -0.36 (p 0.140, n 18), 95% CI -0.71 to +0.13. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.27 (p 0.277, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.39 (p 0.109, n 18). could be the mix.
- skeptic
- leave-one-out range -0.54 to -0.28, sign flips 0; without severely affected donors -0.36 (p 0.140, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SHH in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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