parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in pdcs	0.75
chemistry Open Targets	hard to drug	0.27
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 381	0.91
pathways Reactome	3 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 7803

receipt 7811: SH2B3 in dopamine neurons, braak

power: full sample -0.44 (p 0.069, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.41 (p 0.093, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.46 (p 0.056, n 18). could be the mix.
skeptic: leave-one-out range -0.56 to -0.37, sign flips 0; without severely affected donors -0.44 (p 0.069, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SH2B3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7810: SH2B3 in microglia, braak

power: full sample -0.44 (p 0.069, n 18), 95% CI -0.75 to +0.04. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.50 (p 0.036, n 18). holds up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.45 (p 0.059, n 18). could be the mix.
skeptic: leave-one-out range -0.56 to -0.35, sign flips 0; without severely affected donors -0.44 (p 0.069, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SH2B3 in microglia.

case closed: nothing better to follow up.

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