parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.09 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in choroid plexus epithelial cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	21 Parkinson's papers of 1,824	0.59
pathways Reactome	5 pathways; mostly protein handling	0.90

No case: the score is under the bar. Receipt 3036

receipt 3044: SGK1 in dopamine neurons, braak

power: full sample -0.06 (p 0.820, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.06 (p 0.820, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.09 (p 0.715, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.05, sign flips 4; without severely affected donors -0.06 (p 0.820, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SGK1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3043: SGK1 in oligodendrocytes, braak

power: full sample +0.08 (p 0.767, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.12 (p 0.640, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.08 (p 0.767, n 18). could be the mix.
skeptic: leave-one-out range -0.05 to +0.20, sign flips 3; without severely affected donors +0.08 (p 0.767, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SGK1 in oligodendrocytes.

case closed: nothing better to follow up.

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