parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	group enriched in astrocytes (27 nCPM)	1.00
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	5 Parkinson's papers of 211	0.76
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 9655

receipt 9663: SENP3 in dopamine neurons, braak

power: full sample +0.29 (p 0.243, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.24 (p 0.337, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.27 (p 0.281, n 18). could be the mix.
skeptic: leave-one-out range +0.19 to +0.38, sign flips 0; without severely affected donors +0.29 (p 0.243, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SENP3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9662: SENP3 in astrocytes, braak

power: full sample +0.49 (p 0.038, n 18), 95% CI +0.03 to +0.78. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: +0.50 (p 0.034, n 18). holds up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.58 (p 0.013, n 18). not the mix.
skeptic: leave-one-out range +0.43 to +0.57, sign flips 0; without severely affected donors +0.49 (p 0.038, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SENP3 in astrocytes.

case closed: nothing better to follow up.

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