Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (platelets) | 0.10 |
| chemistry Open Targets | compounds already reach it: bimosiamose, rg-1512, rivipansel +2 | 0.90 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 513 | 0.82 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 4033
Sealed predictions
- SELP in dopamine neurons, braak-0.15 (p 0.702) → -0.21 (p 0.586)receipt 4040
Swarm cases
receipt 4040: SELP in dopamine neurons, braak
- power
- full sample +0.07 (p 0.774, n 18), 95% CI -0.41 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.07 (p 0.794, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
- skeptic
- leave-one-out range -0.04 to +0.20, sign flips 3; without severely affected donors +0.07 (p 0.774, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SELP in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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