Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.08 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in platelets | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 1 stopped | 0.20 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly dopamine synapse | 1.00 |
No case: the score is under the bar. Receipt 3265
Sealed predictions
- SCN1B in dopamine neurons, braak-0.57 (p 0.108) → -0.56 (p 0.114)receipt 3271
Swarm cases
receipt 3271: SCN1B in dopamine neurons, braak
- power
- full sample -0.57 (p 0.013, n 18), 95% CI -0.82 to -0.14. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.59 (p 0.0092, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.59 (p 0.0092, n 18). not the mix.
- skeptic
- leave-one-out range -0.75 to -0.53, sign flips 0; without severely affected donors -0.57 (p 0.013, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SCN1B in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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