Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in kupffer cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 22 Parkinson's papers of 459 | 0.59 |
| pathways Reactome | 5 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 5654
Sealed predictions
- SARM1 in dopamine neurons, braak-0.14 (p 0.714) → -0.78 (p 0.013)receipt 5662
- SARM1 in oligodendrocytes, braak-0.12 (p 0.767) → -0.28 (p 0.459)receipt 5661
Swarm cases
receipt 5662: SARM1 in dopamine neurons, braak
- power
- full sample -0.37 (p 0.130, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.32 (p 0.198, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.063, n 18). could be the mix.
- skeptic
- leave-one-out range -0.52 to -0.28, sign flips 0; without severely affected donors -0.37 (p 0.130, n 18). fragile.
- cell type
- strongest in microglia: -0.69 (p 0.0014, n 18) vs -0.37 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SARM1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SARM1 · microglia · braak: substantia nigra, an independent cohort (already registered)
receipt 5661: SARM1 in oligodendrocytes, braak
- power
- full sample +0.03 (p 0.922, n 18), 95% CI -0.45 to +0.49. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.07 (p 0.794, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.00 (p 0.990, n 18). could be the mix.
- skeptic
- leave-one-out range -0.09 to +0.15, sign flips 6; without severely affected donors +0.03 (p 0.922, n 18). fragile.
- cell type
- strongest in microglia: -0.69 (p 0.0014, n 18) vs +0.03 in oligodendrocytes. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SARM1 in oligodendrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SARM1 · microglia · braak: substantia nigra, an independent cohort: not measured
Receipts
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