Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (rod photoreceptor cells) | 0.10 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 14 Parkinson's papers of 3,969 | 0.64 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7413
Sealed predictions
- SAG in dopamine neurons, braak-0.53 (p 0.145) → -0.29 (p 0.449)receipt 7420
Swarm cases
receipt 7420: SAG in dopamine neurons, braak
- power
- full sample -0.37 (p 0.135, n 18), 95% CI -0.71 to +0.12. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.37 (p 0.135, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.45 (p 0.060, n 18). could be the mix.
- skeptic
- leave-one-out range -0.53 to -0.29, sign flips 0; without severely affected donors -0.37 (p 0.135, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SAG in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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