Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 11 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 8 Parkinson's papers of 3,417 | 0.71 |
| pathways Reactome | 9 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 6631
Sealed predictions
- S100A8 in dopamine neurons, braak-0.79 (p 0.011) → +0.14 (p 0.718)receipt 6638
Swarm cases
receipt 6638: S100A8 in dopamine neurons, braak
- power
- full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.30 (p 0.225, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.201, n 18). could be the mix.
- skeptic
- leave-one-out range -0.50 to -0.26, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for S100A8 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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