Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.04 (overall 0.02) | 0.04 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 7436
Sealed predictions
- RTKN2 in dopamine neurons, braak+0.25 (p 0.517) → +0.34 (p 0.374)receipt 7443
Swarm cases
receipt 7443: RTKN2 in dopamine neurons, braak
- power
- full sample +0.31 (p 0.218, n 18), 95% CI -0.19 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.39 (p 0.109, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.33 (p 0.188, n 18). could be the mix.
- skeptic
- leave-one-out range +0.20 to +0.47, sign flips 0; without severely affected donors +0.31 (p 0.218, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RTKN2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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