Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.03 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | compounds already reach it: ly-2584702, ly-2780301, xl-418 +2 | 0.80 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 309 | 0.71 |
| pathways Reactome | 1 pathway; mostly lysosome and autophagy | 1.00 |
No case: the score is under the bar. Receipt 6799
Sealed predictions
- RPS6KB1 in dopamine neurons, braak+0.42 (p 0.258) → -0.03 (p 0.946)receipt 6807
Swarm cases
receipt 6807: RPS6KB1 in dopamine neurons, braak
- power
- full sample +0.11 (p 0.658, n 18), 95% CI -0.37 to +0.55. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.10 (p 0.696, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.18 (p 0.476, n 18). could be the mix.
- skeptic
- leave-one-out range +0.00 to +0.22, sign flips 1; without severely affected donors +0.11 (p 0.658, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RPS6KB1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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