Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.18 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in gonadotrophs | 0.75 |
| chemistry Open Targets | compounds already reach it: tas0612 | 0.80 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2102
Sealed predictions
- RPS6KA6 in dopamine neurons, braak+0.05 (p 0.892) → +0.41 (p 0.272)receipt 2107
Swarm cases
receipt 2107: RPS6KA6 in dopamine neurons, braak
- power
- full sample +0.33 (p 0.179, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.54 (p 0.021, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.54 (p 0.021, n 18). not the mix.
- skeptic
- leave-one-out range +0.24 to +0.49, sign flips 0; without severely affected donors +0.33 (p 0.179, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RPS6KA6 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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