parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in retinal horizontal cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 170	0.85
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 4878

receipt 4888: RORB in dopamine neurons, braak

power: full sample +0.33 (p 0.176, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.33 (p 0.176, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.36 (p 0.140, n 18). could be the mix.
skeptic: leave-one-out range +0.26 to +0.46, sign flips 0; without severely affected donors +0.33 (p 0.176, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RORB in dopamine neurons.

case closed: nothing better to follow up.

receipt 4887: RORB in astrocytes, braak

power: full sample +0.45 (p 0.059, n 18), 95% CI -0.02 to +0.76. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.40 (p 0.099, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.41 (p 0.093, n 18). could be the mix.
skeptic: leave-one-out range +0.39 to +0.64, sign flips 0; without severely affected donors +0.45 (p 0.059, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RORB in astrocytes.

case closed: nothing better to follow up.

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