parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.04 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in bergmann glia	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	3 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 6028

receipt 6036: ROBO3 in dopamine neurons, braak

power: full sample -0.33 (p 0.182, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.33 (p 0.182, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.022, n 18). not the mix.
skeptic: leave-one-out range -0.48 to -0.24, sign flips 0; without severely affected donors -0.33 (p 0.182, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ROBO3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6035: ROBO3 in astrocytes, braak

power: full sample -0.26 (p 0.289, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.35 (p 0.159, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.34 (p 0.173, n 18). could be the mix.
skeptic: leave-one-out range -0.37 to -0.15, sign flips 0; without severely affected donors -0.26 (p 0.289, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for ROBO3 in astrocytes.

case closed: nothing better to follow up.

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