Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.42 (overall 0.26) | 0.42 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1639
Sealed predictions
- RNF141 in dopamine neurons, braak+0.36 (p 0.347) → -0.35 (p 0.362)receipt 1646
Swarm cases
receipt 1646: RNF141 in dopamine neurons, braak
- power
- full sample -0.15 (p 0.544, n 18), 95% CI -0.58 to +0.34. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.15 (p 0.549, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.16 (p 0.538, n 18). could be the mix.
- skeptic
- leave-one-out range -0.27 to -0.02, sign flips 0; without severely affected donors -0.15 (p 0.544, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RNF141 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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