parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.07 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in neutrophils	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 85	0.85
pathways Reactome	1 pathway; mostly vesicle traffic	1.00

No case: the score is under the bar. Receipt 3630

receipt 3638: RIN3 in dopamine neurons, braak

power: full sample -0.35 (p 0.150, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.32 (p 0.194, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.52 (p 0.026, n 18). not the mix.
skeptic: leave-one-out range -0.50 to -0.27, sign flips 0; without severely affected donors -0.35 (p 0.150, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RIN3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 3637: RIN3 in microglia, braak

power: full sample -0.56 (p 0.016, n 18), 95% CI -0.81 to -0.12. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.66 (p 0.0026, n 18). holds up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.65 (p 0.0036, n 18). not the mix.
skeptic: leave-one-out range -0.70 to -0.51, sign flips 0; without severely affected donors -0.56 (p 0.016, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RIN3 in microglia.

case closed: nothing better to follow up.

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