Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.16 (overall 0.10) | 0.16 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 72 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 2573
Sealed predictions
- RER1 in dopamine neurons, braak+0.20 (p 0.597) → +0.49 (p 0.183)receipt 2580
Swarm cases
receipt 2580: RER1 in dopamine neurons, braak
- power
- full sample +0.41 (p 0.091, n 18), 95% CI -0.07 to +0.74. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.42 (p 0.082, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.047, n 18). not the mix.
- skeptic
- leave-one-out range +0.34 to +0.61, sign flips 0; without severely affected donors +0.41 (p 0.091, n 18). robust.
- cell type
- strongest in astrocytes: +0.67 (p 0.0022, n 18) vs +0.41 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RER1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up RER1 · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.02 p 0.929 (needs p < 6.9e-4)
Receipts
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