parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in fibro-adipogenic progenitors	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 610	0.82
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 11541

receipt 11550: RECK in dopamine neurons, braak

power: full sample -0.10 (p 0.702, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.11 (p 0.677, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.14 (p 0.585, n 18). could be the mix.
skeptic: leave-one-out range -0.23 to +0.02, sign flips 2; without severely affected donors -0.10 (p 0.702, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RECK in dopamine neurons.

case closed: nothing better to follow up.

receipt 11549: RECK in microglia, braak

power: full sample -0.13 (p 0.603, n 18), 95% CI -0.56 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.10 (p 0.696, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.04 (p 0.881, n 18). could be the mix.
skeptic: leave-one-out range -0.28 to -0.05, sign flips 0; without severely affected donors -0.13 (p 0.603, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RECK in microglia.

case closed: nothing better to follow up.

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