Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

RCBTB1

RCC1 and BTB domain containing protein 1

translation score 0.39, read 2026-10-25; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocyte progenitor cells; strongest in cone photoreceptor cells0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		1 Parkinson's papers of 360.91
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 9576

Sealed predictions

  1. RCBTB1 in dopamine neurons, braak+0.00 (p 1.000) → -0.61 (p 0.078)receipt 9585
  2. RCBTB1 in oligodendrocytes, braak+0.41 (p 0.273) → +0.03 (p 0.946)receipt 9584

Swarm cases

receipt 9585: RCBTB1 in dopamine neurons, braak

power
full sample -0.34 (p 0.173, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.32 (p 0.201, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.137, n 18). could be the mix.
skeptic
leave-one-out range -0.44 to -0.26, sign flips 0; without severely affected donors -0.34 (p 0.173, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RCBTB1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9584: RCBTB1 in oligodendrocytes, braak

power
full sample +0.21 (p 0.413, n 18), 95% CI -0.29 to +0.61. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.23 (p 0.355, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.34 (p 0.167, n 18). could be the mix.
skeptic
leave-one-out range +0.11 to +0.38, sign flips 0; without severely affected donors +0.21 (p 0.413, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for RCBTB1 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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