Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly energy | 0.60 |
No case: the score is under the bar. Receipt 10958
Sealed predictions
- RBP1 in dopamine neurons, braak+0.59 (p 0.096) → -0.26 (p 0.504)receipt 10965
Swarm cases
receipt 10965: RBP1 in dopamine neurons, braak
- power
- full sample +0.10 (p 0.683, n 18), 95% CI -0.38 to +0.54. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.11 (p 0.652, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.652, n 18). could be the mix.
- skeptic
- leave-one-out range +0.02 to +0.27, sign flips 0; without severely affected donors +0.10 (p 0.683, n 18). fragile.
- cell type
- strongest in microglia: -0.61 (p 0.0069, n 18) vs +0.10 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RBP1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up RBP1 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.50 p 0.076 (needs p < 2.0e-4)
Receipts
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