Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 88 | 0.82 |
| pathways Reactome | 3 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 8293
Sealed predictions
- RAB8B in dopamine neurons, braak-0.12 (p 0.767) → +0.18 (p 0.648)receipt 8300
Swarm cases
receipt 8300: RAB8B in dopamine neurons, braak
- power
- full sample +0.01 (p 0.983, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.05 (p 0.840, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.06 (p 0.807, n 18). could be the mix.
- skeptic
- leave-one-out range -0.14 to +0.12, sign flips 7; without severely affected donors +0.01 (p 0.983, n 18). fragile.
- cell type
- strongest in microglia: -0.67 (p 0.0024, n 18) vs +0.01 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAB8B in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up RAB8B · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.55 p 0.051 (needs p < 2.6e-4)
Receipts
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