Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PTF1A

pancreas associated transcription factor 1a

translation score 0.34, read 2026-10-26; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas
cell type enriched outside the brain (pancreatic acinar cells)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
1 Parkinson's papers of 4380.91
pathways
Reactome
2 pathways; mostly other0.30

No case: the score is under the bar. Receipt 10590

Sealed predictions

  1. PTF1A in dopamine neurons, braakn/a → n/areceipt 10596

Swarm cases

receipt 10596: PTF1A in dopamine neurons, braak

cell type
PTF1A is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PTF1A in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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