parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.11 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in choroid plexus epithelial cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	2 Parkinson's trials, 0 stopped	1.00
literature PubMed	705 Parkinson's papers of 25,975: well-trodden	0.14
pathways Reactome	13 pathways; mostly growth signalling	0.60

No case: the score is under the bar. Receipt 2446

receipt 2453: PTEN in dopamine neurons, braak

power: full sample +0.37 (p 0.127, n 18), 95% CI -0.11 to +0.72. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.41 (p 0.087, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.41 (p 0.089, n 18). could be the mix.
skeptic: leave-one-out range +0.29 to +0.50, sign flips 0; without severely affected donors +0.37 (p 0.127, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PTEN in dopamine neurons.

case closed: nothing better to follow up.

receipt 2452: PTEN in microglia, braak

power: full sample -0.19 (p 0.460, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.20 (p 0.434, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.14 (p 0.567, n 18). could be the mix.
skeptic: leave-one-out range -0.33 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.460, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PTEN in microglia.

case closed: nothing better to follow up.

loading the receipts