parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in endometrial luminal cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 356	0.91
pathways Reactome	1 pathway; mostly energy	0.60

No case: the score is under the bar. Receipt 9565

receipt 9573: PSAT1 in dopamine neurons, braak

power: full sample +0.19 (p 0.439, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.06 (p 0.827, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.04 (p 0.874, n 18). could be the mix.
skeptic: leave-one-out range +0.10 to +0.34, sign flips 0; without severely affected donors +0.19 (p 0.439, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PSAT1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9572: PSAT1 in oligodendrocytes, braak

power: full sample -0.03 (p 0.901, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.03 (p 0.922, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.02 (p 0.935, n 18). could be the mix.
skeptic: leave-one-out range -0.18 to +0.06, sign flips 5; without severely affected donors -0.03 (p 0.901, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PSAT1 in oligodendrocytes.

case closed: nothing better to follow up.

loading the receipts