Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.05 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | 27 Parkinson's papers of 2,331 | 0.56 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 5177
Sealed predictions
- PRX in dopamine neurons, braak-0.25 (p 0.517) → -0.21 (p 0.591)receipt 5183
Swarm cases
receipt 5183: PRX in dopamine neurons, braak
- power
- full sample -0.21 (p 0.403, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.369, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.23 (p 0.365, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.10, sign flips 0; without severely affected donors -0.21 (p 0.403, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRX in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts