Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.43 (overall 0.26) | 0.43 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in cone photoreceptor cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1630
Sealed predictions
- PRR16 in dopamine neurons, braak+0.75 (p 0.020) → -0.11 (p 0.778)receipt 1637
Swarm cases
receipt 1637: PRR16 in dopamine neurons, braak
- power
- full sample +0.47 (p 0.051, n 18), 95% CI -0.00 to +0.77. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.46 (p 0.056, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.53 (p 0.022, n 18). not the mix.
- skeptic
- leave-one-out range +0.39 to +0.62, sign flips 0; without severely affected donors +0.47 (p 0.051, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRR16 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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