Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.22 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 1883
Sealed predictions
- PPM1D in dopamine neurons, braak-0.29 (p 0.443) → -0.02 (p 0.965)receipt 1890
Swarm cases
receipt 1890: PPM1D in dopamine neurons, braak
- power
- full sample -0.19 (p 0.439, n 18), 95% CI -0.61 to +0.30. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.403, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.22 (p 0.384, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.10, sign flips 0; without severely affected donors -0.19 (p 0.439, n 18). fragile.
- cell type
- strongest in OPCs: -0.67 (p 0.0024, n 18) vs -0.19 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPM1D in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PPM1D · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.00 p 1.000 (needs p < 8.3e-4)
Receipts
loading the receipts