Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in retinal amacrine cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 7402
Sealed predictions
- POU6F2 in dopamine neurons, braak+0.41 (p 0.273) → -0.03 (p 0.946)receipt 7410
- POU6F2 in oligodendrocytes, braak-0.41 (p 0.273) → +0.11 (p 0.778)receipt 7409
Swarm cases
receipt 7410: POU6F2 in dopamine neurons, braak
- power
- full sample +0.32 (p 0.198, n 18), 95% CI -0.17 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.34 (p 0.161, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.24 (p 0.346, n 18). could be the mix.
- skeptic
- leave-one-out range +0.25 to +0.50, sign flips 0; without severely affected donors +0.32 (p 0.198, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for POU6F2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 7409: POU6F2 in oligodendrocytes, braak
- power
- full sample -0.03 (p 0.915, n 18), 95% CI -0.49 to +0.45. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.07 (p 0.787, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.15 (p 0.549, n 18). could be the mix.
- skeptic
- leave-one-out range -0.12 to +0.11, sign flips 5; without severely affected donors -0.03 (p 0.915, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for POU6F2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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