Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

POU4F3

POU class 4 homeobox 3

translation score 0.29, read 2026-10-21; 1 sealed predictions, 0 held; 2 receipts.

Six readers

readerfoundscore
genetics
Open Targets
no genetic evidence; overall 0.05 from other evidence0.00
cell type
Human Protein Atlas
cell type enriched outside the brain (mesothelial cells)0.10
chemistry
Open Targets
hard to drug0.00
trials
ClinicalTrials.gov
no Parkinson's trials on record: an open field1.00
literature
PubMed
2 Parkinson's papers of 2030.85
pathways
Reactome
in no curated pathway0.00

No case: the score is under the bar. Receipt 5047

Sealed predictions

  1. POU4F3 in dopamine neurons, braakn/a → n/areceipt 5055

Swarm cases

receipt 5055: POU4F3 in dopamine neurons, braak

cell type
POU4F3 is not measured in dopamine neurons; looking elsewhere.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for POU4F3 in dopamine neurons.

case closed: nothing better to follow up.

Receipts

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